From the UES:
Take the F train at 63rd & Lex 1 stop to Roosevelt Island. Walk 3 minutes North up Main street. Or Take the free Red Bus 1 stop North on Main Street.
or
Take the Roosevelt Island TRAM at 60th and 2nd. Walk 6 Minutes North up Main Street. Or take the free Red Bus 2 stops North on Main Street.
From Queens:
Take the F train to Roosevelt Island Walk 3 minutes North up Main street. Or Take the free Red Bus 1 stop North on Main Street.
From LIC:
Take the NY Ferry North one stop to Roosevelt Island. Go to Main Street and walk North 6 Minutes to 507 Main Street.